What are the main contraindications of Hyoscine Butylbromide?

• angle-closure glaucoma
• patients with arrhythmias

What are the main adverse effects of Hyoscine Butylbromide?

• tachycardia
• dry mouth
• constipation
• urinary retention in patients with BPH

What is the main clinical use of Hyoscine Butylbromide?

• reducing copious respiratory secretions at end of life
• symptomatic relief for irritable bowel syndrome

What is the method of action of Hyoscine Butylbromide?

competitive inhibitor of acetylcholine which leads to:

• increase heart rate and conduction
• reduce smooth muscle tone and peristaltic contraction
• reduce secretions

What is a long acting Antimuscarinic?

tiotropium, glycopyrronium

What is a short acting Antimuscarinic?

ipratropium

What are the main contraindications of Antimuscarinics?

angle-closure glaucoma

What are the main adverse effects of Antimuscarinics?

dry mouth

What is the main clinical use of Antimuscarinics?

• chronic obstructive pulmonary disease
• asthma

What is the method of action of Antimuscarinics?

• Bind to the muscarinic receptor, where they act as a competitive inhibitor of acetylcholine
• Leading to reduce smooth muscle tone and reduce secretions