All::Respiratory::Pharmacology::H1-receptor antagonists
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What is the method of action of H1-receptor antagonists?
H1 receptors, histamine induces the features of immediate-type (type 1) hypersensitivity
H1-receptor antagonistsWhat is the main clinical use of H1-receptor antagonists?
- Allergies, particularly hay fever
- To aid relief of pruritus and urticaria
- Adjunctive treatment in anaphylaxis
What are the main contraindications of H1-receptor antagonists?
severe liver disease
H1-receptor antagonistsWhy do first-generation H1-receptor antagonists cause sedation?
They cross the blood brain barrier and H1 receptors, has a role in the brain in maintaining wakefulness
H1-receptor antagonistsWhat is an example of a first-generation H1-receptor antagonists?
chlorphenamine
H1-receptor antagonistsWhat is an example of a second-generation H1-receptor antagonists?
loratadine, cetirizine and fexofenadine
H1-receptor antagonists