What is the method of action of Aminosalicylates?

• releasing 5-aminosalicylic acid which has anti-inflammatory and immunosuppressive effects
• This appears to act topically on the gut rather than systemically

What is the main clinical use of Aminosalicylates?

• First-line mild-to-moderate ulcerative colitis
• Rheumatoid arthritis (only sulfapyridine)

What are the main contraindications of Aminosalicylates?

Should be avoided in patients with aspirin hypersensitivity