What is the method of action of Phenothiazines?

The antiemetic properties are from blockade of:

• dopamine receptors in the CTZ and gut
• to a lesser extent, histamine and acetylcholine receptors in the vomiting centre and vestibular system

What is the main clinical use of Phenothiazines?

• nausea and vomiting in a wide range of conditions, particularly when due to vertigo
• Psychotic disorders

What are the main adverse effects of Phenothiazines?

• Drowsiness
• Postural hypotension
• Extrapyramidal syndromes

What are the main contraindications of Phenothiazines?

Severe liver disease

What is an example of Phenothiazines?

Prochlorperazine