What is the method of action of Aminoglycosides?

• enter bacterial cells via an oxygen-dependent transport system
• bind irreversibly to bacterial ribosomes and inhibit protein synthesis

What are the main adverse effects of Aminoglycosides?

• nephrotoxicity
• ototoxicity

What is the spectrum of coverage of Aminoglycosides?

• Gram-negative aerobic bacteria
• staphylococci
• mycobacteria

What microbes will Aminoglycosides be effective against?

streptococci and anaerobes