All::Gastroenterology::Pharmacology::Dopamine D2-receptor antagonists
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What is the method of action of Dopamine D2-receptor antagonists?
- The D2 receptor is the main receptor in the chemoreceptor trigger zone
- Blocking D2 receptors have a prokinetic effect and promoting gastric emptying
What is the main clinical use of Dopamine D2-receptor antagonists?
- Nausea and vomiting, particularly in the context of reduced gut motility.
What are the main adverse effects of Dopamine D2-receptor antagonists?
- Diarrhoea
- Extrapyramidal syndromes
What are the main contraindications of Dopamine D2-receptor antagonists?
- Extrapyramidal side effects are more common in children and young adults
- Avoid in gastrointestinal obstruction and perforation
What are some examples of Dopamine D2-receptor antagonists?
- metoclopramide
- domperidone