All::Haematology::Diseases::Chronic myeloid leukaemia
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What is the common presentation of Chronic myeloid leukaemia?
anaemia: lethargy weight loss and sweating are common splenomegaly may be marked → abdo discomfort
Chronic myeloid leukaemiaWhat patient groups is Chronic myeloid leukaemia most common?
60-70 years
Chronic myeloid leukaemiaWhat is the management of Chronic myeloid leukaemia?
- imatinib is now considered first-line treatment
- hydroxyurea
- interferon-alpha
- allogenic bone marrow transplant
What is seen on bloods in Chronic myeloid leukaemia?
- an increase in granulocytes at different stages of maturation +/- thrombocytosis
- decreased leukocyte alkaline phosphatase
- may undergo blast transformation (AML in 80%, ALL in 20%)
What chromosome is usually found in patients with Chronic myeloid leukaemia?
Philadelphia chromosome
Chronic myeloid leukaemiaWhat is the cause of the Philadelphia chromosome?
translocation between the long arm of chromosome 9 and 22 - t(9:22)(q34; q11)
Chronic myeloid leukaemiaWhat is the pathophysiology of Chronic myeloid leukaemia?
The abnormal BCR-ABL gene codes for a fusion protein that has tyrosine kinase activity in excess of normal.
Chronic myeloid leukaemiaWhat is the method of action of imatinib?
inhibitor of the tyrosine kinase
Chronic myeloid leukaemia