All::Haematology::Diseases::Chronic myeloid leukaemia

Study All (8) Add to study queue (8)

Intro

Study Intro (8) Add to study queue (8)

What is the common presentation of Chronic myeloid leukaemia?

anaemia: lethargy weight loss and sweating are common splenomegaly may be marked → abdo discomfort

Chronic myeloid leukaemia

What patient groups is Chronic myeloid leukaemia most common?

60-70 years

Chronic myeloid leukaemia

What is the management of Chronic myeloid leukaemia?

  • imatinib is now considered first-line treatment
  • hydroxyurea
  • interferon-alpha
  • allogenic bone marrow transplant

Chronic myeloid leukaemia

What is seen on bloods in Chronic myeloid leukaemia?

  • an increase in granulocytes at different stages of maturation +/- thrombocytosis
  • decreased leukocyte alkaline phosphatase
  • may undergo blast transformation (AML in 80%, ALL in 20%)

Chronic myeloid leukaemia

What chromosome is usually found in patients with Chronic myeloid leukaemia?

Philadelphia chromosome

Chronic myeloid leukaemia

What is the cause of the Philadelphia chromosome?

translocation between the long arm of chromosome 9 and 22 - t(9:22)(q34; q11)

Chronic myeloid leukaemia

What is the pathophysiology of Chronic myeloid leukaemia?

The abnormal BCR-ABL gene codes for a fusion protein that has tyrosine kinase activity in excess of normal.

Chronic myeloid leukaemia

What is the method of action of imatinib?

inhibitor of the tyrosine kinase

Chronic myeloid leukaemia