What is Amiodarone?

a class III antiarrhythmic agent used in the treatment of atrial, nodal and ventricular tachycardias

Whats the MOA of Amiodarone ?

main mechanism of action is by blocking potassium channels which inhibits repolarisation and hence prolongs the action potential.

What are the adverse effects of amiodarone use?

• thyroid dysfunction: both hypothyroidism and hyper-thyroidism
• corneal deposits
• pulmonary fibrosis/pneumonitis
• liver fibrosis/hepatitis
• peripheral neuropathy, myopathy
• photosensitivity
• 'slate-grey' appearance
• thrombophlebitis and injection site reactions (should be given via large veins)
• bradycardia
• lengths QT interval