All::Haematology::Diseases::Burkitt's lymphoma
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What is Burkitt's lymphoma?
a high-grade B-cell neoplasm
Burkitt's lymphomaWhat are the two major types of Burkitt's lymphoma?
- endemic (African) form: typically involves maxilla or mandible
- sporadic form: abdominal (e.g. ileo-caecal) tumours are the most common form. More common in patients with HIV
What gene abnormality is associated with Burkitt's lymphoma?
c-myc gene translocation, usually t(8:14)
Burkitt's lymphomaWhat virus is implicated in the development of the African form of Burkitt's lymphoma and to a lesser extent the sporadic form?
Epstein-Barr virus
Burkitt's lymphomaWhat is seen under microscopy in Burkitt's lymphoma?
'starry sky' appearance: lymphocyte sheets interspersed with macrophages containing dead apoptotic tumour cells
Burkitt's lymphomaTreatment of Burkitt's lymphoma with chemotherapy can commonly cause what?
tumour lysis syndrome
Burkitt's lymphomaWhat are the findings in tumour lysis syndrome?
- hyperkalaemia
- hyperphosphataemia
- hypocalcaemia
- hyperuricaemia
- acute renal failure