What are the main causes of Restrictive cardiomyopathy?

• amyloidosis (e.g. secondary to myeloma) - most common cause in UK
• haemochromatosis
• post-radiation fibrosis
• Loffler's syndrome: endomyocardial fibrosis with a prominent eosinophilic infiltrate
• endocardial fibroelastosis: thick fibroelastic tissue forms in the endocardium; most commonly seen in young children
• sarcoidosis
• scleroderma

What is the pathophysiology of Restrictive cardiomyopathy?

• primarily characterized by decreased compliance of the ventricular endomyocardium
• causes predominately diastolic dysfunction

What is the most common cause of Restrictive cardiomyopathy in the UK?

amyloidosis