All::Haematology::Diseases::Alpha-thalassaemia
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What is Alpha-thalassaemia?
a group of disorders of haemoglobin synthesis, caused by mutations or deletions in at least 1 of the 4 alpha-globin genes
Alpha-thalassaemiaAlpha-thalassaemia
If 1 or 2 alpha globulin alleles are affected how would the patient be effected?
the blood picture would be hypochromic and microcytic, but the Hb level would be typically normal
Alpha-thalassaemiaAlpha-thalassaemia
If 3 alpha globulin alleles are affected how would the patient be effected?
a hypochromic microcytic anaemia with splenomegaly. This is known as Hb H disease
Alpha-thalassaemiaAlpha-thalassaemia
If 4 alpha globulin alleles are affected how would the patient be effected?
then death in utero
Alpha-thalassaemia