What are Adenosine diphosphate (ADP) receptor inhibitors?

A group of anti-platelet medication

What are some examples of Adenosine diphosphate (ADP) receptor inhibitors?

• Clopidogrel
• Prasugrel
• Ticagrelor
• Ticlopidine

What's the MOA of Adenosine diphosphate (ADP) receptor inhibitors?

Adenosine diphosphate (ADP) is one of the main platelet activation factors, mediated by G-coupled receptors P2Y1 and P2Y12. The main target of ADP receptor inhibition is the P2Y12 receptor, as it is the one which leads to sustained platelet aggregation and stabilisation of the platelet plaque.

What are notable side effects of ticagrelor?

may cause dyspnoea

What is the interaction with clopidogrel and proton pump inhibitors

leading to reducing antiplatelet effects

What are the absolute contraindications of prasugrel use?

Patients with prior stroke or transient ischaemic attack, high risk of bleeding, and prasugrel hypersensitivity

What are the absolute contraindications of Ticagrelor use?

a high risk of bleeding, those with a history of intracranial haemorrhage, and those with severe hepatic dysfunction