What is the method of action of Carbimazole

blocks thyroid peroxidase from coupling and iodinating the tyrosine residues on thyroglobulin → reducing thyroid hormone production

What is the main clinical use of Carbimazole

management of thyrotoxicosis

What is the main adverse effects of Carbimazole

• agranulocytosis
• crosses the placenta, but may be used in low doses during pregnancy

What's the initial dose regime of Carbimazole?

given in high doses for 6 weeks until the patient becomes euthyroid before being reduced.