What is the method of action of Thiazide diuretics

inhibit sodium reabsorption at the beginning of the distal convoluted tubule (DCT) by blocking the thiazide-sensitive Na+-Cl− symporter

What is the main clinical use of Thiazide diuretics

• hypertension
• heart failure

What is the main adverse effects of Thiazide diuretics

• dehydration
• postural hypotension
• hyponatraemia, hypokalaemia, hypercalcaemia*
• gout
• impaired glucose tolerance
• impotence

What are some of the rare side effects of Thiazide diuretics?

• thrombocytopaenia
• agranulocytosis
• photosensitivity rash
• pancreatitis