What is the method of action of Nitrates

• nitrates cause the release of nitric oxide in smooth muscle, activating guanylate cyclase which then converts GTP to cGMP, which in turn leads to a fall in intracellular calcium levels
• in angina they both dilate the coronary arteries and also reduce venous return which in turn reduces left ventricular work, reducing myocardial oxygen demand

What is the main clinical use of Nitrates

management of angina and the acute treatment of heart failure

What is the main adverse effects of Nitrates

• hypotension
• tachycardia
• headaches
• flushing