All::Cardiovascular System::Pharmacology::Adenosine

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Intro

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Adenosine is most commonly used to terminate what?

supraventricular tachycardias

Adenosine

The effects of adenosine are enhanced by {{c1::dipyridamole antiplatelet agent}} and blocked by {{c2::theophyllines}}

Adenosine

What group is Adenosine contraindicated in?

asthmatics

Adenosine

Mechanism of action

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What's the primary MOA of Adenosine?

Causes transient heart block in the AV node

Adenosine

How does Adenosine cause AV block

agonist of the A1 receptor in the atrioventricular node, which inhibits adenylyl cyclase thus reducing cAMP and causing hyperpolarization by increasing outward potassium flux

Adenosine

What's adenosine half life

very short, about 8-10 seconds

Adenosine