All::Cardiovascular System::Pharmacology::Adenosine
Intro
Adenosine is most commonly used to terminate what?
supraventricular tachycardias
The effects of adenosine are enhanced by {{c1::dipyridamole antiplatelet agent}} and blocked by {{c2::theophyllines}}
What group is Adenosine contraindicated in?
asthmatics
Mechanism of action
..
What's the primary MOA of Adenosine?
Causes transient heart block in the AV node
How does Adenosine cause AV block
agonist of the A1 receptor in the atrioventricular node, which inhibits adenylyl cyclase thus reducing cAMP and causing hyperpolarization by increasing outward potassium flux
What's adenosine half life
very short, about 8-10 seconds