All::Nephrology::Diseases::Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)
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What is Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)?
a rare type of small-vessel vasculitis associated with both pulmonary haemorrhage and rapidly progressive glomerulonephritis
Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)Whats the alternative name for Goodpasture's syndrome?
Anti-glomerular basement membrane disease
Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)What causes Goodpasture's syndrome?
caused by anti-glomerular basement membrane (anti-GBM) antibodies against type IV collagen
Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)What groups is Goodpasture's syndrome more common in?
- men (sex ratio 2:1)
- peaks in 20-30 and 60-70 age brackets
What are the features of Goodpasture's syndrome?
- pulmonary haemorrhage
- rapidly progressive glomerulonephritis
What is seen on renal biopsy in Goodpasture's syndrome?
linear IgG deposits along the basement membrane
Anti-glomerular basement membrane (GBM) disease (Goodpasture's syndrome)What's the management of Goodpasture's syndrome
- plasma exchange (plasmapheresis)
- steroids
- cyclophosphamide
What increases the risk of pulmonary haemorrhage in Goodpasture's syndrome?
- smoking
- lower respiratory tract infection
- pulmonary oedema
- inhalation of hydrocarbons
- young males