What is the method of action of Aldosterone antagonists?

Inhibit effect of aldosterone by competitively binding to the aldosterone receptor

What is the main clinical use of Aldosterone antagonists?

• Ascites and oedema due to liver cirrhosis
• Chronic heart failure
• Primary hyperaldosteronism (for patients waiting or unsuitable for surgical management)

What are the main adverse effects of Aldosterone antagonists?

• Hyperkalaemia
• Gynaecomastia

What are the main contraindications of Aldosterone antagonists?

• Hyperkalaemia
• Addison’s disease
• Should also be avoided in pregnant or lactating women