What is the method of action of Adrenaline?

Potent agonist of the α1, α2, β1 and β2 adrenoceptors.

What is the main clinical use of Adrenaline?

• Cardiac arrest
• Anaphylaxis
• Injected locally to stop bleeding

What are the cardiac effects of Adrenaline?

• Vasoconstriction of vessels supplying skin, mucosa and abdominal viscera
• Increasing heart rate, force of contraction and myocardial excitability
• Vasodilatation of vessels supplying the heart and muscles

What are the non-cardiac effects of Adrenaline?

• Bronchodilatation
• Suppression of inflammatory mediator release from mast cells

What is an important drug interaction of Adrenaline?

β-blocker, as adrenaline may induce widespread vasoconstriction, because its α1-mediated vasoconstricting effect is not opposed by β2-mediated vasodilatation.