All::Endocrinology::Pharmacology::Sulfonylureas

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Intro

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What is the method of action of Sulfonylureas?

increasing pancreatic insulin secretion by binding to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells

Sulfonylureas

What is the main clinical use of Sulfonylureas?

management of type 2 diabetes mellitus

Sulfonylureas

What are the main adverse effects of Sulfonylureas?

  • hypoglycaemic episodes
  • weight gain

Sulfonylureas

What are the main contraindications of Sulfonylureas?

breastfeeding and pregnancy

Sulfonylureas

What are some rare side effects of Sulfonylureas?

  • hyponatraemia secondary to syndrome of inappropriate ADH secretion
  • bone marrow suppression
  • hepatotoxicity
  • peripheral neuropathy

Sulfonylureas