What is the method of action of Sulfonylureas?

increasing pancreatic insulin secretion by binding to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells

What is the main clinical use of Sulfonylureas?

management of type 2 diabetes mellitus

What are the main adverse effects of Sulfonylureas?

• hypoglycaemic episodes
• weight gain

What are the main contraindications of Sulfonylureas?

breastfeeding and pregnancy

What are some rare side effects of Sulfonylureas?

• hyponatraemia secondary to syndrome of inappropriate ADH secretion
• bone marrow suppression
• hepatotoxicity
• peripheral neuropathy