All::Rheumatology::Diseases::Systemic sclerosis
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What is systemic sclerosis?
A condition with hardened skin and connective tissues, more common in females.
Systemic sclerosisHow many patterns of disease are there?
Three patterns: Limited, Diffuse, and Scleroderma without internal organ involvement.
Systemic sclerosisWhat is CREST syndrome?
A subtype of limited systemic sclerosis: Calcinosis, Raynaud's, Esophageal dysmotility, Sclerodactyly, Telangiectasia.
Systemic sclerosisWhat's associated with limited systemic sclerosis?
Raynaud's, face and limb involvement, and anti-centromere antibodies.
Systemic sclerosisWhat's associated with diffuse systemic sclerosis?
Trunk and limb involvement, anti scl-70 antibodies, and respiratory complications.
Systemic sclerosisHow is Scleroderma without internal organ involvement characterized?
Tightening and fibrosis of the skin, manifesting as plaques or linear patterns.
Systemic sclerosisWhat antibodies are associated with systemic sclerosis?
ANA positive in 90%, RF positive in 30%, anti-scl-70 with diffuse, and anti-centromere with limited.
Systemic sclerosis