All::Rheumatology::Diseases::Systemic lupus erythematosus
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What are the general features of Systemic Lupus Erythematosus (SLE)?
Fatigue, fever, mouth ulcers, and lymphadenopathy.
Systemic lupus erythematosusWhat are the skin manifestations of SLE?
Malar (butterfly) rash (spares nasolabial folds), discoid rash (scaly, erythematous, well-demarcated, in sun-exposed areas), photosensitivity, Raynaud's phenomenon, livedo reticularis, and non-scarring alopecia.
Systemic lupus erythematosusWhat musculoskeletal symptoms can occur in SLE?
Arthralgia and non-erosive arthritis.
Systemic lupus erythematosusWhat are the cardiovascular manifestations of SLE?
Pericarditis (most common), myocarditis.
Systemic lupus erythematosusWhat respiratory symptoms are associated with SLE?
Pleurisy and fibrosing alveolitis.
Systemic lupus erythematosusWhat renal complications can arise in SLE?
Proteinuria and glomerulonephritis (with diffuse proliferative glomerulonephritis being the most common type).
Systemic lupus erythematosusWhat neuropsychiatric symptoms may occur in SLE?
Anxiety, depression, psychosis, and seizures.
Systemic lupus erythematosusWhat antibodies are commonly positive in systemic lupus erythematosus (SLE)?
ANA (99% positive), anti-dsDNA (70% sensitive, >99% specific), anti-Smith, anti-U1 RNP, SS-A, and SS-B.
Systemic lupus erythematosusHow is ANA used in the diagnosis of SLE?
Highly sensitive (99%), useful rule-out test, but low specificity.
Systemic lupus erythematosusWhat markers are monitored in SLE, and what indicates active disease?
ESR (commonly used), CRP (may be normal), low complement levels (C3, C4), and anti-dsDNA titers for disease monitoring.
Systemic lupus erythematosus