All::Rheumatology::Pharmacology::Sulfasalazine

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What is Sulfasalazine used for?

It is a DMARD used for inflammatory arthritis, especially rheumatoid arthritis, and inflammatory bowel disease.

Sulfasalazine

How does Sulfasalazine work?

It is a prodrug for 5-ASA, decreasing neutrophil chemotaxis, suppressing lymphocyte proliferation, and reducing pro-inflammatory cytokines.

Sulfasalazine

What are the cautions for using Sulfasalazine?

G6PD deficiency, allergy to aspirin or sulphonamides (cross-sensitivity).

Sulfasalazine

What are the adverse effects of Sulfasalazine?

Oligospermia, Stevens-Johnson syndrome, pneumonitis/lung fibrosis, myelosuppression, Heinz body anemia, megaloblastic anemia; may color tears and stain contact lenses.

Sulfasalazine

Is Sulfasalazine safe during pregnancy and breastfeeding?

Yes, unlike other DMARDs, it is considered safe to use during both pregnancy and breastfeeding.

Sulfasalazine