All::Rheumatology::Diseases::Sjogren's syndrome

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What is Sjogren's syndrome?

An autoimmune disorder affecting exocrine glands, causing dry mucosal surfaces.

Sjogren's syndrome

Who does Sjogren's syndrome primarily affect?

It is much more common in females (ratio 9:1).

Sjogren's syndrome

What is the increased risk associated with Sjogren's syndrome?

Marked increased risk of lymphoid malignancy (40-60 fold).

Sjogren's syndrome

What are the common features of Sjogren's syndrome?

Dry eyes, dry mouth, vaginal dryness, arthralgia, Raynaud's, myalgia, sensory polyneuropathy, recurrent parotitis, and subclinical renal tubular acidosis.

Sjogren's syndrome

Which antibodies are often positive in Sjogren's syndrome?

Anti-Ro (SSA) antibodies (70% in primary Sjogren's), anti-La (SSB) antibodies (30%), RF (50%), and ANA (70%).

Sjogren's syndrome

How is tear formation measured in Sjogren's syndrome?

Schirmer's test, placing filter paper near the conjunctival sac to measure tear production.

Sjogren's syndrome

What is the management for Sjogren's syndrome?

Artificial saliva and tears, and pilocarpine may stimulate saliva production.

Sjogren's syndrome