All::Rheumatology::Diseases::Polyarteritis nodosa

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What is Polyarteritis Nodosa (PAN)?

PAN is a vasculitis affecting medium-sized arteries, characterized by necrotizing inflammation leading to aneurysm formation.

Polyarteritis nodosa

Who is more commonly affected by PAN, and what is it associated with?

PAN is more common in middle-aged men and is associated with hepatitis B infection.

Polyarteritis nodosa

What are the clinical features of PAN?

Fever, malaise, arthralgia, weight loss, hypertension, mononeuritis multiplex, sensorimotor polyneuropathy, testicular pain, livedo reticularis, haematuria, renal failure.

Polyarteritis nodosa

What antibodies are found in around 20% of patients with 'classic' PAN?

Perinuclear-antineutrophil cytoplasmic antibodies (ANCA).

Polyarteritis nodosa

What percentage of PAN patients have positive hepatitis B serology?

30% of patients with PAN have positive hepatitis B serology.

Polyarteritis nodosa