All::Rheumatology::Diseases::Paget's disease of the bone
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What is Paget's disease primarily characterized by?
Increased, uncontrolled bone turnover, mainly a disorder of osteoclasts.
Paget's disease of the boneWhat are common sites affected by Paget's disease?
Skull, spine/pelvis, and long bones of the lower extremities.
Paget's disease of the boneWhat factors predispose individuals to Paget's disease?
Increasing age, male sex, northern latitude, and family history.
Paget's disease of the boneWhat are typical clinical features of Paget's disease?
Bone pain (pelvis, lumbar spine, femur), raised alkaline phosphatase (ALP), bowing of tibia, and bossing of the skull.
Paget's disease of the boneWhat complications can arise from Paget's disease?
The text does not provide information on complications.
Paget's disease of the boneWhat complications can arise from Paget's disease involving the skull?
Deafness due to cranial nerve entrapment, skull thickening.
Paget's disease of the boneWhat potential serious complication is associated with long-term Paget's disease?
Bone sarcoma, with a 1% risk if affected for more than 10 years.
Paget's disease of the boneWhat cardiovascular complication can occur with Paget's disease?
High-output cardiac failure.
Paget's disease of the boneWhat skeletal complications are associated with Paget's disease?
Fractures due to bone involvement.
Paget's disease of the bone