All::Rheumatology::Diseases::Drug-induced lupus

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How does drug-induced lupus differ from systemic lupus erythematosus (SLE)?

In drug-induced lupus, not all typical SLE features are present, and renal/nervous system involvement is uncommon. It usually resolves upon stopping the causative drug.

Drug-induced lupus

What are common features of drug-induced lupus?

Arthralgia, myalgia, common skin (malar rash), and pulmonary involvement (pleurisy). Renal and nervous system involvement is unusual.

Drug-induced lupus

What antibodies are commonly found in drug-induced lupus?

ANA positive in 100%, dsDNA negative, and anti-histone antibodies in 80-90%. Anti-Ro, anti-Smith positive in around 5%.

Drug-induced lupus

Name two most common causes of drug-induced lupus.

Procainamide and hydralazine.

Drug-induced lupus

Mention less common causes of drug-induced lupus.

Isoniazid, minocycline, and phenytoin.

Drug-induced lupus