All::Rheumatology::Pharmacology::Azathioprine
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What is the active compound produced when azathioprine is metabolized?
Mercaptopurine, which is a purine analogue inhibiting purine synthesis.
AzathioprineWhat test might be necessary to identify individuals prone to azathioprine toxicity?
Thiopurine methyltransferase (TPMT) test.
AzathioprineWhat are the adverse effects of azathioprine?
Bone marrow depression (monitor with full blood count), nausea/vomiting, pancreatitis, and an increased risk of non-melanoma skin cancer.
AzathioprineHow should azathioprine doses be adjusted when used concurrently with allopurinol?
Lower doses should be used due to a significant interaction.
AzathioprineIs azathioprine considered safe for use during pregnancy?
Yes, azathioprine is generally considered safe to use in pregnancy.
Azathioprine