All::Psychiatry::Pharmacology::Tricyclic antidepressants
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What is the method of action of Tricyclic antidepressants?
- Act mainly on inhibition of the reuptake of neurotransmitters Serotonin & Noradrenaline
- Also antagonism of histamine, muscarinic and adrenergic receptors (which explains its side effect profile)
What is the main clinical use of Tricyclic antidepressants?
- neuropathic pain
- previously used in depression but now rarely used
What are the main adverse effects of Tricyclic antidepressants?
- drowsiness
- dry mouth
- blurred vision
- constipation
- urinary retention
- postural hypotension
- lengthening of QT interval