What is the pathophysiology of Alcohol withdrawal?

decreased inhibitory GABA and increased NMDA glutamate transmission

What are the typical early symptoms of Alcohol withdrawal?

tremor, sweating, tachycardia, anxiety

In Alcohol withdrawal when is the peak incidence of seizures?

36 hours

What are the symptoms of delirium tremens?

• coarse tremor
• confusion
• delusions
• auditory and visual hallucination
• fever
• tachycardia

During Alcohol withdrawal when is the peak incidence of delirium tremens?

48-72 hours

What is the first line treatment for Alcohol withdrawal?

long-acting benzodiazepines