What is the common presentation of IgA nephropathy?

macroscopic haematuria in young people following an upper respiratory tract infection

What is seen in histology in IgA nephropathy?

mesangial hypercellularity, positive immunofluorescence for IgA & C3

What is the pathophysiology of IgA nephropathy?

thought to be caused by mesangial deposition of IgA immune complexes

What is the prognosis of IgA nephropathy?

• 25% of patients develop ESRF
• markers of good prognosis: frank haematuria

When are ACE inhibitors indicated in IgA nephropathy?

persistent proteinuria (above 500 to 1000 mg/day)

Whats the treatment for IgA nephropathy after no improvement with ACE inhibitors and falling eGFR?

immunosuppression with corticosteroids

How long after an infection does IgA nephropathy develop?

1-2 days