All::Nephrology::Diseases::Focal segmental glomerulosclerosis

Study All (5) Add to study queue (5)

Intro

Study Intro (5) Add to study queue (5)

What is Focal segmental glomerulosclerosis?

a cause of nephrotic syndrome and chronic kidney disease. It generally presents in young adults.

Focal segmental glomerulosclerosis

What is the management of Focal segmental glomerulosclerosis?

steroids +/- immunosuppressants

Focal segmental glomerulosclerosis

What are the main causes of Focal segmental glomerulosclerosis?

  • idiopathic
  • secondary to other renal pathology e.g. IgA nephropathy, reflux nephropathy
  • HIV
  • heroin
  • Alport's syndrome
  • sickle-cell

Focal segmental glomerulosclerosis

What is the prognosis of Focal segmental glomerulosclerosis?

  • untreated FSGS has a < 10% chance of spontaneous remission
  • a high recurrence rate in renal transplants

Focal segmental glomerulosclerosis

What is seen in renal biopsy in Focal segmental glomerulosclerosis?

  • focal and segmental sclerosis and hyalinosis on light microscopy
  • effacement of foot processes on electron microscopy

Focal segmental glomerulosclerosis