What is Peutz-Jeghers syndrome?

hereditary condition characterised by numerous hamartomatous polyps in the gastrointestinal tract (mainly small bowel)

What is the inheritance pattern of Peutz-Jeghers syndrome?

autosomal dominant

What are the main clinical features of Peutz-Jeghers syndrome?

• numerous hamartomatous polyps in the gastrointestinal tract (mainly small bowel)
• pigmented lesions on lips, oral mucosa, face, palms and soles

What is the management of Peutz-Jeghers syndrome?

conservative

What are the main causes of Peutz-Jeghers syndrome?

responsible gene encodes serine threonine kinase LKB1 or STK11

What are the common complications of Peutz-Jeghers syndrome?

• small bowel obstruction is a common presenting complaint, often due to intussusception
• gastrointestinal bleeding
• increased life time risk of GI cancers