All::Neurology::Diseases::Huntington's disease
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What is the inheritance pattern of Huntington's disease?
autosomal dominant - anticipation may be seen
Huntington's diseaseWhat are the main clinical features of Huntington's disease?
- chorea
- personality changes (e.g. irritability, apathy, depression) and intellectual impairment
- dystonia
- saccadic eye movements
What is the pathophysiology of Huntington's disease?
- results in degeneration of cholinergic and GABAergic neurons in the striatum of the basal ganglia
- due to defect in huntingtin gene on chromosome 4
What is Huntington's disease?
an inherited neurodegenerative condition. It is a progressive and incurable condition that typically results in death 20 years after the initial symptoms develop.
Huntington's diseaseWhen do symptoms of Huntington's disease develop?
~35
Huntington's diseaseWhat is the life expectancy of someone with Huntington's disease?
death 20 years after the initial symptoms develop
Huntington's disease