All::Endocrinology::Diseases::Multiple endocrine neoplasia
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What is Multiple endocrine neoplasia?
a condition which encompasses several distinct syndromes featuring tumours of endocrine glands
Multiple endocrine neoplasiaWhat is the inheritance pattern of Multiple endocrine neoplasia?
autosomal dominant
Multiple endocrine neoplasiaWhat cancers are associated with MEN type I?
- Parathyroid (95%): hyperparathyroidism due to parathyroid hyperplasia
- Pituitary (70%)
- Pancreas (50%): e.g. insulinoma, gastrinoma (leading to recurrent peptic ulceration)
What cancers are associated with MEN type IIa?
- Medullary thyroid cancer (70%)
- Parathyroid (60%)
- Phaeochromocytoma
What cancers are associated with MEN type IIb?
- Medullary thyroid cancer
- Phaeochromocytoma
- Neuromas