All::Respiratory::Diseases::Microscopic polyangiitis

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Intro

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What are the main clinical features of Microscopic polyangiitis?

  • renal impairment: raised creatinine, haematuria, proteinuria
  • fever
  • other systemic symptoms: lethargy, myalgia, weight loss
  • rash: palpable purpura
  • cough, dyspnoea, haemoptysis
  • mononeuritis multiplex

Microscopic polyangiitis

What is Microscopic polyangiitis?

a small-vessel ANCA vasculitis

Microscopic polyangiitis

Which antibodies are seen in Microscopic polyangiitis?

  • pANCA (against MPO) - positive in 50-75%
  • cANCA (against PR3) - positive in 40%

Microscopic polyangiitis