What is an Insulinoma?

a neuroendocrine tumour deriving mainly from pancreatic Islets of Langerhans cells

What is the most common pancreatic endocrine tumour?

Insulinoma

What are the features of Insulinoma?

• of hypoglycaemia: typically early in morning or just before meal, e.g. diplopia, weakness etc
• rapid weight gain may be seen
• high insulin, raised proinsulin:insulin ratio
• high C-peptide

What is seen on bloods in Insulinoma?

• high insulin
• raised proinsulin:insulin ratio
• high C-peptide

What is management of insulinoma?

• surgery
• diazoxide and somatostatin if patients are not candidates for surgery