All::Gastroenterology::Diseases::Dubin-Johnson syndrome

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Intro

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What is the inheritance pattern of Dubin-Johnson syndrome?

autosomal recessive

Dubin-Johnson syndrome

What are the main clinical features of Dubin-Johnson syndrome?

hyperbilirubinaemia (conjugated, therefore present in urine)

Dubin-Johnson syndrome

What is the pathophysiology of Dubin-Johnson syndrome?

defect in the canillicular multispecific organic anion transporter (cMOAT) protein. This causes defective hepatic bilirubin excretion

Dubin-Johnson syndrome