What patient groups is Autoimmune hepatitis most common?

most commonly seen in young females

What are the main clinical features of Autoimmune hepatitis?

• may present with signs of chronic liver disease
• acute hepatitis: fever, jaundice etc (only 25% present in this way)
• amenorrhoea (common)

What is the management of Autoimmune hepatitis?

• steroids, other immunosuppressants e.g. azathioprine
• liver transplantation

What are the recognised associations of Autoimmune hepatitis?

other autoimmune disorders, hypergammaglobulinaemia and HLA B8, DR3

What antibodies are found in Autoimmune hepatitis?

ANA/SMA/LKM1 antibodies, raised IgG levels

What is seen on liver biopsy in Autoimmune hepatitis?

inflammation extending beyond limiting plate 'piecemeal necrosis', bridging necrosis

What are the features of Type I Autoimmune hepatitis?

• Anti-nuclear antibodies (ANA) and/or anti-smooth muscle antibodies (SMA)
• Affects both adults and children

What are the features of Type II Autoimmune hepatitis?

• Anti-liver/kidney microsomal type 1 antibodies (LKM1)
• Affects children only

What are the features of Type III Autoimmune hepatitis?

• Soluble liver-kidney antigen
• Affects adults in middle-age